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目的探讨NHERF1和β-catenin在基底细胞癌组织中的表达及其意义。方法应用免疫组化方法检测48例基底细胞癌及30例正常表皮石蜡组织切片中NHERF1和β-catenin的表达。结果 NHERF1和β-catenin在基底细胞癌组织中细胞浆呈明显高表达,表达率分别为56.25%和77.08%;两者在正常表皮中均呈低表达。基底细胞癌细胞浆中NHERF1表达与β-catenin表达呈正相关(r=0.418,P<0.05)。结论 NHERF1和β-catenin的异常表达与基底细胞癌的发生可能有关。
Objective To investigate the expression and significance of NHERF1 and β-catenin in basal cell carcinoma. Methods Immunohistochemistry was used to detect the expressions of NHERF1 and β-catenin in 48 cases of basal cell carcinoma and 30 cases of normal epidermis. Results The expression of NHERF1 and β-catenin in basal cell carcinoma was significantly higher than that in normal epithelium (56.25% and 77.08% respectively). Both of them showed low expression in normal epidermis. NHERF1 expression in basal cell carcinoma was positively correlated with the expression of β-catenin (r = 0.418, P <0.05). Conclusion The abnormal expression of NHERF1 and β-catenin may be related to the occurrence of basal cell carcinoma.