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目的 探索爆震后豚鼠耳蜗 Corti隧道中传出神经纤维损伤情况。方法 复制强脉冲噪声致聋豚鼠模型 ,暴露后 3,2 1 d进行耳蜗乙酰胆碱脂酶染色、铺片 ,计算机辅助定量研究穿越耳蜗 Corti隧道中传出神经纤维。结果 暴露后穿越耳蜗 Corti隧道中传出神经纤维损伤主要发生在耳蜗第一回和第二回 ,暴露后各组耳蜗第一回、第二回每 0 .2 4mm穿越耳蜗 Corti隧道中传出神经纤维数分别为 :暴露后 3d组 (9.6± 4.2 )、(8.8± 3.4)根 ;暴露后 2 1 d组 (1 1 .4± 3.2 )、(1 0 .6± 2 .5 )根 ;而正常对照组(2 3.2± 3.2 )、(2 0 .7± 2 .9)根 ;两实验组与正常对照组间统计学差异有显著意义。结论 强脉冲噪声暴露后耳蜗 Corti隧道中传出神经纤维变性坏死
Objective To explore the damage of nerve fibers in the Corti tunnel of guinea pig cochlea after detonation. Methods The model of guinea pig deafness induced by strong impulse noise was reproduced. The cochlear acetylcholinesterase staining was performed on day 3 and day 21 after exposure. The neurological fibers were dissected through Corti tunnel via computer assisted quantitative study. Results After exposure, Corti tunnel traversing the cochlear tunnel revealed nerve fiber damage mainly in the first and second cochlear cochlea. After the exposure, the cochlea of each group was exposed for the first time, and the second time every 0.24 mm of Corti tunnel passed through the cochlea The number of fibers were: post-exposure 3d group (9.6 ± 4.2), (8.8 ± 3.4) roots; 21d group after exposure (11.4 ± 3.2) and (106.6 ± 2.5) The normal control group (2 3.2 ± 3.2), (2 0 .7 ± 2 .9) roots; two experimental groups and the normal control group statistically significant difference. Conclusion The impulse nerves degenerated and necrotic in Corti tunnel after exposure to strong impulsive noise