Mobile wireless sensor network ( WSN) composed by mobile terminals has a dynamic topology and can be widely used in various fields.However, the lack of centralized control, dynamic topology and limited energy supply make the network layer of mobile WSN be vulnerable to multiple attacks, such as black hole ( BH) , gray hole ( GH) , flooding attacks ( FA) and rushing attacks ( RU) .Ex-isting researches on intrusion attacks against mobile WSN, currently, tend to focus on targeted de-tection of certain types of attacks.The defense methods also have clear directionality and is unable to deal with indeterminate intrusion attacks.Therefore, this work will design an indeterminate intru-sion attack oriented detecting and adaptive responding mechanism for mobile WSN.The proposed mechanism first uses a test sliding window ( TSW) to improve the detecting accuracy, then constructs parameter models of confidence on attack ( COA) , network performance degradation ( NPD) and adap-tive responding behaviors list, finally adaptively responds according to the decision table,so as to im-prove the universality and flexibility of the detecting and adaptive responding mechanism.The simula-tion results show that the proposed mechanism can achieve multiple types of intrusion detecting in multiple attack scenarios, and can achieve effective response under low network consumption.