英国医学研究人员发明了一种巧妙地处理人和啮齿动物的基因的方法,以产生能攻击和破坏有害细胞如癌细胞的超抗体。医学研究院分子生物实验室和剑桥大学病理系的研究人员将从大鼠取得的抗体蛋白段片与人抗体结合。结果形成一种杂交抗体,这种抗体结合了啮齿动物抗体破坏有害细胞的作用和人的抗体避免机体排斥的能力。研究人员从注入人白细胞的大鼠体内分离出抗体。一些鼠的抗体具有抗一种特殊人体蛋白或抗原(CAMPATH-1)的活性。CAM-PATH-1是一种抗原,出现在一些成熟的白细胞上,而不是在由成熟白细胞衍生的幼龄细胞即干细胞上。称为高变异区的大鼠抗体部分具有结合此抗原的活性。研究人 British medical researchers invented a clever way to deal with human and rodent genes to produce antibodies that attack and destroy harmful cells such as cancer cells. Researchers from Molecular Biology Laboratories, Medical Research Institute and Department of Pathology, University of Cambridge, will combine antibody fragments obtained from rats with human antibodies. The result is a hybrid antibody that combines the ability of rodent antibodies to destroy unwanted cells and the ability of human antibodies to avoid body rejection. The researchers isolated antibodies from human white blood cells injected into rats. Some mouse antibodies have activity against a specific human protein or antigen (CAMPATH-1). CAM-PATH-1 is an antigen that appears on some mature white blood cells rather than young cells that are derived from mature white blood cells, ie, stem cells. The part of the rat antibody called the hypervariable region has the activity of binding to this antigen. Researcher