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1894年英国的 Payne 首次用抗疟药奎宁治疗盘状红斑狼疮(DLE)。但是直到1951年 Page 用阿的平治疗 DLE 有效的报告,才确立了此类药治疗非疟疾的用途。各种抗疟药——阿的平、氯喹和羟氯喹对一些皮肤病是有效的。但是后两者可能造成不可逆的视网膜病,从而降低了人们早先对此类药的热情。一、化学性质和代谢氯喹和羟氯喹的基本化学结构是4-氨基醌核(4-aminoquinolone nucleus)。阿的平与其不同的是有一额外的苯环而成为吖啶化合物。但4—氨基醌核仍是所有的抗疟药的基本结构。抗疟药味苦,溶解于水,几乎完全由胃
1894 British Payne for the first time with anti-malarial quinine treatment of discoid lupus erythematosus (DLE). However, it was not until the 1951 page that Aripiprazole was effective in treating DLE, establishing the use of such drugs in the treatment of non-malaria. A variety of anti-malarial drugs - A, chloroquine and hydroxychloroquine for some skin diseases are effective. However, the latter two may cause irreversible retinopathy, thereby reducing the previous enthusiasm for such drugs. First, the chemical nature and metabolism The basic chemical structure of chloroquine and hydroxychloroquine is 4-amino quinolone nucleus (4-aminoquinolone nucleus). A flat with its difference is an additional benzene ring and become acridine compounds. But 4-amino quinone nucleus is still the basic structure of all antimalarial drugs. Antimalarial is bitter, soluble in water, almost exclusively by the stomach