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目的 观察哮喘发作期及缓解期患者食管 2 4hpH的变化 ,研究胃食管反流 (GER)病人应用抑酸剂后食管 pH或肺功能的改变情况。方法 对 5 1例哮喘病人进行了研究 ,其中 30例病人比较发作期及缓解 2周后的 2 4h食管 pH指标 ,对 16例伴有GER的哮喘缓解期病人 ,应用奥米拉唑治疗 ,比较治疗前及治疗 2周后肺功能指标。对 15例伴有GER的急性哮喘发作病人应用奥米拉唑治疗 ,比较治疗前及治疗 2周后 2 4h食管 pH的变化。结果 哮喘发作期及缓解期 2 4h食管pH各项指标与正常对照组比较显著升高 (P <0 0 1)。 16例伴有GER的哮喘缓解期病人 ,应用抑酸剂后肺功能有明显改善 (P <0 0 5 )。 15例伴有GER的哮喘急性发作期病人经抑酸剂治疗后 ,13例食管 2 4hpH监测的各项指标明显降低 (P <0 0 1)。结论 哮喘急性发作期及缓解期 ,GER发生率显著升高 ,有GER的哮喘病人肺功能有明显改变 ,对哮喘发作的病人 ,需常规进行食管 2 4hpH监测 ,发现有GER的病人 ,可采取质子泵抑制剂治疗
Objective To observe the change of esophageal 24 hpH in patients with asthma attack and remission, and to study the changes of esophageal pH or pulmonary function in patients with gastroesophageal reflux disease (GER). Methods A total of 51 asthmatic patients were studied. Thirty patients underwent 24 h esophageal pH index at the onset and 2 weeks after remission. 16 patients with asthma remission with GER were treated with omeprazole. Lung function before treatment and after 2 weeks of treatment. Omeprazole was given to 15 patients with acute asthma attack accompanied by GER. The changes of esophageal pH were compared before and after 2 weeks of treatment. Results The indexes of esophageal pH at 24 hours after asthma attack and remission were significantly higher than those in normal controls (P <0.01). 16 cases of patients with remission of asthma with GER, pulmonary function was significantly improved (P <0 05). Fifteen patients with acute exacerbation of asthma accompanied by GER after antacid therapy, 13 cases of esophageal 24 hpH monitoring indicators were significantly reduced (P <0.01). Conclusions The acute exacerbation of asthma and remission period, the incidence of GER was significantly increased, with asthma GER asthma patients had significant changes in the performance of asthma attack patients need to routine esophageal 24 hpH monitoring found that patients with GER can take protons Pump inhibitor treatment