人和大鼠类胰岛素生长因子-I(IGF-I)浓度受营养摄取的调节。有报告营养物质的供给能调节由营养控制的基因转译,诸如:铁蛋白、白蛋白以及前胰岛素等。因此推测食物蛋白的摄取能在转译水平上调节 IGF-I 基因的表达。在正常动物,IGF-I mRNA 可转录成号码不同的级别,而在限制蛋白的动物则未能观察到。作者观察正常饲养和限制蛋白饲养的大鼠,肝脏对 IGF-I mRNA 号码级别的转录不同,借以估 The concentrations of human and rat insulin-like growth factor-I (IGF-I) are regulated by nutrient uptake. It has been reported that the supply of nutrients can regulate the translation of genes controlled by nutrition, such as ferritin, albumin and proinsulin. Therefore, it is speculated that the uptake of food protein can regulate the expression of IGF-I gene at translation level. In normal animals, IGF-I mRNA can be transcribed to different numbers but not to protein-restricted animals. The authors observed that in normal and limiting protein fed rats, the liver differed in IGF-I mRNA number-