目的探讨全凭静脉麻醉甲状腺癌根治手术中使用右美托咪定药物的临床疗效。方法选取我院近年收治的患者共76例,随机将其分为对照组及观察组。对照组患者采用浓度为0.9%的氯化钠注射液静脉泵注,观察组患者则使用负荷量每千克0.7μg的右美托咪定静脉泵注。之后两组均使用顺式阿曲库铵与丙泊酚诱导插管。取检测时点:T1(给药之前)、T2(给药10 min)、T3(建立气腔)、T4(将甲状腺肿物切除)、T5(手术结束),分别检测两组患者HR(心率)、MAP(平均动脉压)、Sp O2(脉搏血氧饱和度)情况。结果两组患者T1时点各项指标差异均无统计学意义(P>0.05),从T2开始出现明显变化,在T3、T4两个时点时两组比较差异有统计学意义(P<0.05),但Sp O2情况始终未出现明显变化。手术情况方面,两组患者在麻醉诱导时间以及苏醒时间差异无统计学意义(P>0.05),但在丙泊酚用量上,观察组用量明显相对偏少(P<0.05)。结论在全凭静脉麻醉甲状腺癌根治手术中使用右美托咪定药物能够有效对手术过程中心血管反应产生抑制效果,同时控制丙泊酚用量,减轻患者体内麻药剂量。 Objective To investigate the clinical efficacy of dexmedetomidine in radical thyroidectomy with total intravenous anesthesia. Methods A total of 76 patients admitted to our hospital in recent years were randomly divided into control group and observation group. Patients in the control group received intravenous sodium chloride injection at a concentration of 0.9%, while those in the observation group received a dexmedetomidine infusion of 0.7 μg / kg. Both groups then received cisatracurium and propofol for intubation. The detection time point was T1 (before administration), T2 (administration for 10 min), T3 (establishment of air cavity), T4 (resection of thyroid tumor) and T5 (end of operation) ), MAP (mean arterial pressure), Sp O2 (pulse oximetry). Results There was no significant difference between the two groups at T1 (P> 0.05), but significant changes occurred at T2. There were significant differences between the two groups at T3 and T4 (P <0.05) ), But the Sp O2 situation has not changed significantly. There was no significant difference in anesthesia induction time and recovery time between the two groups (P> 0.05). However, the dosage of propofol was significantly lower in the observation group (P <0.05). Conclusion The use of dexmedetomidine in the radical surgery of thyroid cancer by total intravenous anesthesia can effectively inhibit the cardiovascular response during the operation. At the same time, the dosage of propofol can be controlled and the dosage of anesthetic in the body reduced.