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20世纪60年代凝血因子浓缩物的发现改善了血友病患者的生命质量,提高了他们的生活期望值,使他们几乎能像正常人一样生活。由于凝血因子浓缩物是由成千上百份血浆制成的,供者中出现的每种传染病常传播给血友病患者。在受感染的血友病患者中,主要输血传播传染病为HIV、甲肝、乙肝、丙肝、微小病毒B19。其它传染病如庚肝和TTV在血友病中感染率较高,但它们的临床意义不明显。在英国,1985年前输凝血因子的患者,有30％感染HIV的可能性,98％暴露于丙肝,50％暴露于乙肝。85％抗-HCV阳性血友病患者发展为慢性感染,与此对应的是乙肝感染者仅有4％为血行进感染。1985年血液制品的病毒灭活技术的应用从根本上杜绝了HIV、HBV、HCV通过血
The discovery of clotting factor concentrates in the 1960s improved the quality of life of people with hemophilia and raised their expectations of life so that they could live almost as well as normal people. Since clotting factor concentrates are made from thousands of plasma, every infectious disease that occurs in donors is often transmitted to hemophiliacs. Among the infected hemophiliacs, the major transfusion-transmitted diseases are HIV, hepatitis A, hepatitis B, hepatitis C and parvovirus B19. Other infectious diseases such as hepatitis G and TTV have a higher infection rate in hemophilia, but their clinical significance is not obvious. In the UK, patients who had pre-1985 coagulation factors had a 30% chance of contracting HIV, 98% were exposed to hepatitis C and 50% were exposed to hepatitis B. Eighty-five percent of patients with anti-HCV positive haemophilia develop chronic infection, corresponding to only 4% of those with hepatitis B who have blood-borne infections. The application of virus inactivation technology of blood products in 1985 fundamentally put an end to HIV, HBV, HCV through the blood