目的明确人感染高致病性禽流感疫情的发生,探讨感染来源,以采取相应措施控制疫情的发生。方法采用现场流行病学调查和实验室检测相结合的方法对深圳宝安区1例人感染高致病性禽流感病例个案疫情进行分析。结果该例病例无明确的家禽接触及进食史,病人发病前经常在有大量各类野生候鸟活动的栖息地附近晨练。实验室检测发现该例病毒与香港2011年禽流感死亡的野鸟病毒基因接近,与家禽较远。结论该病例是2011年中全国唯一的1例人禽流感确诊病例,感染途径很可能与野生候鸟有关,建议在冬春季节提醒群众尽量避免直接接触野生候鸟及其排泄物。 Objective To clarify the incidence of human infection with HPAI and explore the sources of infection so as to take appropriate measures to control the occurrence of the outbreak. Methods The epidemic situation of a human case of HPAI in Shenzhen Baoan District was analyzed by a combination of field epidemiological investigation and laboratory test. Results The case did not have a clear history of poultry exposure and consumption. Before the onset of the disease, the patient often performed morning exercises near a habitat with a large variety of wild migratory birds. Laboratory tests revealed that the virus was close to that of the bird flu virus that died of the bird flu in Hong Kong in 2011, far away from poultry. Conclusions This case was the only one confirmed case of bird flu in China in 2011. The route of infection is likely to be related to wild migratory birds. It is suggested that people should be reminded in winter and spring to avoid direct contact with wild migratory birds and their excrement.