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量子点(quantum dots,QDs)是一种小型(直径1~10 nm)半导体纳米晶体,凭借其高亮度、耐光漂白等优点在生物医学领域中被广泛应用。同时,量子点的细胞毒性已受到越来越多的关注,量子点在体外和活体2方面均存在生殖毒性,并随着量子点浓度升高和其释放的Cd2+量的增加,产生的细胞毒性逐渐增强,不同的微环境对相同种类、相同浓度量子点造成的毒性大小也有差异。量子点对生物生殖系统的毒性的影响主要通过细胞死亡受体途径、普遍应激途径、氧化应激途径使组织和细胞发生氧化损伤和凋亡,活性氧自由基(reactive oxygen species,ROS)的产生是量子点引起细胞毒性的因素之一。
Quantum dots (QDs) are small (1 to 10 nm in diameter) semiconductor nanocrystals that are widely used in the biomedical field due to their high brightness, lightfastness and bleaching resistance. At the same time, the cytotoxicity of quantum dots has received more and more attention. The quantum dots have reproductive toxicity both in vitro and in vivo. With the increase of quantum dot concentration and the release of Cd2 +, the cytotoxicity Gradually enhanced, different microenvironment on the same species, the same concentration of quantum dots caused by the size of the toxicity there are differences. The effects of quantum dots on the toxicity of the biological reproductive system are mainly caused by oxidative damage and apoptosis of tissues and cells through the cell death receptor pathway, the universal stress pathway and the oxidative stress pathway. The effects of reactive oxygen species (ROS) Genesis is one of the factors that cause cytotoxicity in quantum dots.