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目的 :总结左旋门冬酰胺酶在儿童淋巴系统恶性肿瘤联合化疗时的严重毒副作用 ,以提高临床认识。方法 :对 130例儿童恶性淋巴系统肿瘤应用左旋门冬酰胺酶后的临床表现、理化检查进行分析。结果 :130例中发生急性超敏反应 6例 ,急性胰腺损害 11例 ,其中急性胰腺炎 6例 ,糖尿病 2例 ,同时合并胰腺炎、糖尿病或酮症酸中毒 3例 ,左旋门冬酰胺酶相关性脑病 3例 ,颅内出血 1例 ,Ⅳ级肝功能损害 4例。结论 :左旋门冬酰胺酶应用过程中可发生严重毒副作用 ,一旦发生 ,须及时予相应治疗
Objectives: To summarize the serious side effects of L-asparaginase in the chemotherapy of children with lymphatic system malignancy in order to improve clinical understanding. Methods: The clinical manifestations and physicochemical examinations of L-asparaginase in 130 children with malignant lymphatic system tumors were analyzed. RESULTS: Acute hypersensitivity occurred in 6 of 130 cases, and 11 cases of acute pancreatic injury, including 6 cases of acute pancreatitis, 2 cases of diabetes, and 3 cases of pancreatitis, diabetes or ketoacidosis, associated with L-Asparaginase. There were 3 cases of encephalopathy, 1 case of intracranial hemorrhage, and 4 cases of grade IV liver dysfunction. Conclusion: Serious side effects can occur during the application of L-asparaginase. Once it occurs, it must be treated accordingly.