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目的了解22个家庭HP感染状况及其对儿童HP感染的影响。方法应用HP尿素酶IgG抗体(ELISA)的方法检测218位4～14岁儿童血清中HP-IgG抗体,并在218位小儿中选择其居住、生活条件基本相同的HP阳性患儿12例,阴性患儿10例,将其父母作为调查对象,并对其父母进行血清抗HP-IgG检测。结果HP阳性患儿的父母HP阳性率为66.6%,HP阴性患儿的父母HP阳性率15.0%,两组差异有非常显著性(P<0.01)。结论子女抗体阳性的父母的抗体阳性率显著高于子女抗体阴性的父母的抗体阳性率,提示HP感染在家庭内有聚集现象。
Objectives To understand the HP infection status of 22 families and their impact on children with HP infection. Methods Serum HP-IgG antibodies in 218 children aged 4-14 years old were detected by HP urease IgG antibody (ELISA). Twelve of 218 children with identical HP who lived in the same living conditions were selected, 10 cases of children, their parents as a survey, and their parents serum anti-HP-IgG test. Results The positive rate of HP was 66.6% in HP positive children and 15.0% in HP negative children, the difference between the two groups was significant (P <0.01). Conclusion The antibody positive rate of the children with positive antibody was significantly higher than the antibody positive rate of the antibody negative parents, suggesting that HP infection accumulated in the family.