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目的:调查分析某医院轻中度烧伤患者质子泵抑制药(PPIs)使用情况,为临床合理用药提供依据。方法:抽取2016年1-12月轻中度烧伤病历804份(轻度370例,中度434例),对使用PPIs的品种、剂型、不合理使用及应激性溃疡(SU)风险因素等情况进行调查分析。结果:在轻中度烧伤804例中,有257例使用了PPIs,占32.0%;其中轻度烧伤使用62例(16.8%),中度烧伤使用195例(44.9%)。在使用PPIs 257例中,口服给药118例(45.9%),注射给药139例(54.1%);使用不合理88例(34.2%),其中疗程过长56例(63.6%)、无适应证用药21例(23.9%)、用法用量不当11例(12.5%)位居前3位。257例中,存在SU风险因素58例,占22.6%,其中严重感染12例(13.6%)、脏器移植术后10例(11.4%)、长期应用免疫抑制药6例(6.8%)位居前3位。结论:某医院轻中度烧伤患者在PPIs选药、给药途径、用法用量、给药时机、疗程等方面存在不合理性,应采取相应措施加以纠正。
Objective: To investigate the use of proton pump inhibitors (PPIs) in patients with mild to moderate burns in a hospital and provide the basis for clinical rational drug use. Methods: Totally 804 mild to moderate burns records (370 mild and 434 moderate) were collected from January to December in 2016. The risk factors, such as variety, dosage form, unreasonable use and stress ulcer (SU) Situation investigation and analysis. Results: Of the 804 mild to moderate burns, 257 used PPIs, accounting for 32.0%; 62 (16.8%) were mild burns and 195 (44.9%) were moderate burns. Of the 257 PPIs used, 118 (45.9%) were given orally and 139 (54.1%) were given by injection; 88 (34.2%) were irrational, 56 (63.6% 21 cases (23.9%) were treated with syndromes, and 11 cases (12.5%) were in the top 3 in terms of improper usage and dosage. Of the 257 patients, 58 were SU risk factors, accounting for 22.6%, of which 12 were severe infections (13.6%), 10 (11.4%) were organ transplantations and 6 (6.8%) were long-term immunosuppressive drugs Top 3. Conclusion: Patients with mild-to-moderate burn in a hospital have some unreasonable aspects in drug selection, administration route, usage dosage, timing and treatment course of PPIs. Some measures should be taken to correct them.