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目的对三联疗法治疗HP阳性消化性溃疡疗效进行评价、分析。方法将我院286例病例随机分为两组,实验组方法为枸橼酸铋钾110mg,每天4次,餐前30分钟与睡前口服;阿莫西林500mg,甲硝唑200mg,每日三次.奥美拉唑20mg,每天一次,疗程为四周.对照组予以奥美拉唑20mg,每天两次,疗程为四周。结果两组治疗效果比较,差异有统计学意义(P<0.05);但两组HP根除率及不良反应复发率比较,实验组明显低于对照组,有显著差异(P<0.05)。结论奥美拉唑三联疗法治疗HP阳性胃溃疡具有显著的效果,HP根除率较高,促进溃疡愈合,同时不良反应发生率低,有较高的安全性,临床应用价值较高。
Objective To evaluate the efficacy of triple therapy in the treatment of HP-positive peptic ulcer. Methods 286 cases of our hospital were randomly divided into two groups, the experimental group method for the bismuth potassium citrate 110mg, 4 times a day, 30 minutes before meals and bedtime oral; amoxicillin 500mg metronidazole 200mg three times a day Omeprazole 20mg, once daily, for four weeks.Omeprazole in the control group was given 20mg twice daily for four weeks. Results There was significant difference between the two groups (P <0.05). However, the eradication rate of HP and the recurrence rate of adverse reactions in both groups were significantly lower than those in the control group (P <0.05). Conclusion Omeprazole triple therapy has a significant effect on the treatment of HP-positive gastric ulcer. HP eradication rate is higher, promote ulcer healing, with a lower incidence of adverse reactions, higher safety and higher clinical value.