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巨噬细胞是人体抵抗病原的第一道防线,在人体的免疫系统中发挥着重要作用,其在机体的新陈代谢、生长发育、组织修复以及稳态的维持等过程中也同样扮演着不可替代的角色,因此,巨噬细胞在靶向治疗多种疾病方面存在巨大潜力。同时,随着实验研究技术的不断发展,人类对于巨噬细胞的认识也得以发展,而这些研究成果将为巨噬细胞作为最具潜力的临床靶标的提供有效理论依据。故,对近年来不同组织定居巨噬细胞的起源和特异性发展,以及其在机体稳态和疾病时自我更新机制的研究进展,进行简单概述,将帮助我们全面了解巨噬细胞的功能特征,这对研究其在新陈代谢疾病、免疫疾病、组织修复、肿瘤及炎症等多种疾病的防治中作为治疗靶点具有重要意义,对人类抵抗疾病具有重大意义。
Macrophages are the first line of defense against pathogens in the human body and play an important role in the body’s immune system. Macrophages play an irreplaceable role in the body’s metabolism, growth and development, tissue repair and homeostasis As a result, macrophages have great potential for targeting the treatment of many diseases. At the same time, with the continuous development of experimental research techniques, human understanding of macrophages has also been developed, and these findings will provide an effective theoretical basis for macrophages as the most potential clinical targets. Therefore, the research on the origin and specific development of macrophages colonized by different tissues in recent years and the progress of their self-renewal mechanism in homeostasis and disease, a brief overview, will help us to fully understand the functional characteristics of macrophages, This is of great significance for the study of its therapeutic targets in the prevention and treatment of various diseases such as metabolic diseases, immune diseases, tissue repair, tumors and inflammation, and is of great significance to human disease resistance.