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为探讨血清和尿中假尿苷（ψ）对恶性肿瘤的诊断价值，用高效液相色谱法测定了５０例正常人、６８例鼻咽癌、４２例原发性肝癌、４１例肺癌、２４例急性白血病和相应部位良性疾病患者血清和尿中ψ的含量。正常人的血清和尿中ψ水平分别为３．０８±０．４９ｎｍｏｌ／ｍｌ、２１．６±２．９ｎｍｏｌ／μｍｏｌ肌酐。鼻咽癌、原发性肝癌、肺癌、急性白血病患者血清ψ分别为４．３２±１．４０、６．７４±３．４４、５．１０±１．９２、６．００±２．０１ｎｍｏｌ／ｍｌ，尿ψ分别为２８．６±６．２、３６．９±１１．７、３１．９±８．３、３５．８±７．０ｎｍｏｌ／μｍｏｌ肌酐，均分别高于相应部位良性疾病患者和参考值。ψ升高的程度与肿瘤大小及分期正相关，且随病情缓解而下降。表明血清和尿中ψ用于鼻咽癌、原发性肝癌、肺癌、急性白血病等恶性肿瘤的诊断，特别是观察病情和疗效有较高的应用价值。
In order to investigate the diagnostic value of pseudouridine (ψ) in serum and urine for malignant tumors, 50 normal subjects, 68 nasopharyngeal carcinomas, 42 primary liver cancers, 41 lung cancers, 24 were determined by HPLC. The serum and urine levels of sputum in patients with acute leukemia and corresponding benign diseases. The levels of serum and urine in healthy persons were 3.08±0.49 nmol/ml and 21.6±2.9 nmol/μmol creatinine, respectively. The seroconvulsions in patients with nasopharyngeal carcinoma, primary liver cancer, lung cancer, and acute leukemia were 4.32±1.40, 6.74±3.44, 5.10±1.92, and 6.00±2.01 nmol/ respectively. The creatinine levels in ml and urinary fistula were 28.6±6.2, 36.9±11.7, 31.9±8.3, and 35.8±7.0 nmol/μmol, respectively, which were higher than those in benign diseases. And reference values. The degree of sputum elevation was positively correlated with tumor size and stage, and decreased with the disease. It is indicated that serum and urinary sputum is used for the diagnosis of nasopharyngeal carcinoma, primary liver cancer, lung cancer, acute leukemia and other malignancies, especially for the observation of the condition and curative effect.