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含有杂原子(氧、氮)的不饱和中环(8~10)广泛分布于具有良好生理活性的天然产物以及药物分子中.然而,因为分子内张力的存在,合成中环类化合物一直是有机化学领域非常具有挑战性的课题.目前对这一结构单元的构建主要通过烯烃的复分解关环反应来实现,其它有效的方法相对较少.兰州大学功能有机分子化学国家重点实验室厍学功课题组发展了一种基于Au催化的1,2-酰氧基重排/分子内[3+2]环加成反应,在温和的条件下制备了一系列不饱和
Unsaturated central rings (8-10) containing heteroatoms (oxygen, nitrogen) are widely distributed in natural products and drug molecules with good physiological activity, however, the synthesis of mesocyclic compounds has always been the field of organic chemistry due to the intramolecular tension Very challenging issues.Construction of this structural unit is mainly achieved through olefin metathesis ring-closure reaction, and other effective methods are relatively small.Lanzhou University State Key Laboratory of Functional Organic Molecular Chemistry Based on the Au-catalyzed 1,2-acyloxy rearrangement / intramolecular [3 + 2] cycloaddition reaction, a series of unsaturated