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目的探讨生化调制剂醛氢叶酸（ＣＦ）和氟脲嘧啶联合应用治疗胃肠道肿瘤的效果。方法采用ＣＦ＋５＿ＦＵ＋ＤＤＰ或／和ＭＭＣ联合方案。ＣＦ用中剂量２００－３００ｍｇ／（ｍ２·ｄ）静脉滴注，２ｈ后接着用５－ＦＵ３７５ｍｇ／（ｍ２·ｄ）静脉滴注ＤＤＰ２０ｍｇ／（ｍ２·ｄ）静脉推注，以上药物连用５ｄ，ＭＭＣ６－８ｍｇ于化疗第１天静脉推注。结果３２例可评价的胃癌有效率（ＣＲ＋ＰＲ）为６２５％，治疗有效病例，治疗后生存３－１４个月，仍在继续观察中。３６例可评价的结直肠癌有效率为４１７％，有效病例中位生存期１３个月，无效病例８个月。毒副反应以骨髓抑制和消化道反应为主。结论本方案对晚期胃肠道肿瘤是一种疗效比较好的化疗方案，毒副反应可以忍受，值得推广。
Objective To investigate the effect of biochemical modulators of leucovorin (CF) and fluorouracil in the treatment of gastrointestinal cancer. Methods CF+5_FU+DDP or/and MMC combined protocol was used. CF was intravenously infused at a medium dose of 200-300 mg/(m2·d), followed by intravenous infusion of DFU 20 mg/(m2·d) intravenously with 5-FU 375 mg/(m2·d) for 2 h, and the drug was used for 5 d, MMC6. -8 mg was injected intravenously on the first day of chemotherapy. Results 32 cases of evaluable gastric cancer effective rate (CR + PR) of 62 5%, the treatment of effective cases, survived 3-14 months after treatment, is still under observation. The effective rate of colorectal cancer in 36 cases was 41.7%, the median survival time of effective cases was 13 months, and the invalid cases were 8 months. The toxic side effects were mainly myelosuppression and gastrointestinal reactions. Conclusion This protocol is a good curative effect for advanced gastrointestinal cancer. The toxicity can be tolerated and worthy of promotion.