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通过对一个大型女性队列的前瞻性研究,验证增加镁摄入量是否可降低心血管疾病的风险,包括心肌梗死和脑卒中。用一个半定量食物频率表评价39876名健康的职业女性(年龄:39~89岁),没有心血管疾病病史或者癌症。在平均10年的随访中,发生了1037例心血管疾病事件,包括280例非致死性心肌梗死和368例脑卒中。经调整年龄和随机治疗后,镁摄入与发生心血管疾病风险之间无有意义的联系。镁摄入量的最高五分值(中位数433 m g/d)与最低五分值(中位数255 m g/d)相比发生总的心血管疾病的相对危险度是0.87(95%可信区间:0.72~1.05,P=0.24),冠心病的相对危险度是0.88(95%可信区间:0.70~1.12,P=0.34),非致死性心肌梗死的相对危险度是1.03(95%可信区间:0.72~1.49,P=0.96),因心血管疾病死亡是1.11(95%可信区间:0.61~2.00,P=0.95),总的脑卒中是0.87(95%可信区间:0.64~1.18,P=0.55)。调整其他心血管疾病危险因素后,没有从实质上改变观察到的零相关。总之,这种结果不支持镁摄入量增多可降低发生冠心病风险的假说,尽管与脑卒中之间弱的负相关还不能排除。
In a prospective study of a large female cohort, we examined whether increasing magnesium intake could reduce the risk of cardiovascular disease, including myocardial infarction and stroke. A semi-quantitative food frequency questionnaire was used to evaluate 39,876 healthy working women (aged 39-89 years) with no history of cardiovascular disease or cancer. During an average of 10 years of follow-up, 1,037 cardiovascular events occurred, including 280 nonfatal myocardial infarctions and 368 stroke patients. After adjustment for age and randomized treatment, there was no meaningful association between magnesium intake and the risk of developing cardiovascular disease. The relative risk for the highest cardiovascular score in total magnesium intake (median 433 mg / d) compared with the lowest quintile (median 255 mg / d) was 0.87 (95% The relative risk for coronary heart disease was 0.88 (95% confidence interval: 0.70 to 1.12, P = 0.34), and the relative risk for non-fatal myocardial infarction was 1.03 (95% confidence interval 0.72 to 1.05, P = 0.24) (95% CI: 0.61 to 2.00, P = 0.95), and overall stroke was 0.87 (95% confidence interval: 0.64 ~ 1.18, P = 0.55). After adjusting for other cardiovascular risk factors, the observed zero correlations have not materially changed. In conclusion, this finding does not support the hypothesis that increased magnesium intake can reduce the risk of coronary heart disease, although a weak negative correlation with stroke can not be ruled out.