目的　研究脑梗塞是否存在家族聚集性。方法　采用病例对照研究 ,对哈尔滨市 95个脑梗塞先证家系和 95个对照家系进行了脑梗塞家族史的遗传易感性的研究。结果　病例和对照家系年龄及性别有良好的均衡 ,病例组一级亲属总的患病率为 16 94% ,与对照组的 3 70 %相比 ,有显著性差异 (χ2 =81 32 ,P <0 0 1) ,不论其父母或同胞 ,均以病例亲属的患病率显著高于对照 ,而子女两者无显著性差异 ;二项分布分析显示 ,脑梗塞家族中实际发病数超过其二项分布的理论概率范围 ,即脑梗塞的分布呈明显的家族聚集性 ;单因素和多因素Logistic回归模型拟合也提示 ,遗传因素在脑梗塞发病中有重要地位。结论　脑梗塞存在家族聚集性 Objective To investigate the existence of familial aggregation in cerebral infarction. Methods A case-control study was conducted to investigate the genetic susceptibility of a family history of cerebral infarction to 95 probands and 95 control subjects of cerebral infarction in Harbin. Results The age and sex of the pedigrees were well balanced. The overall prevalence of first-degree relatives in the case group was 1694%, which was significantly different from that of the control group (χ2 = 81 32, P < 0 0 1), regardless of their parents or siblings, the prevalence of case relatives was significantly higher than the control, while children had no significant difference between the two; two distribution analysis showed that the actual incidence of stroke in the family than its two Distribution of the theoretical probability range, that cerebral infarction distribution was significantly familial aggregation; univariate and multivariate logistic regression model fitting also suggests that genetic factors in the pathogenesis of cerebral infarction has an important position. Conclusion There is familial aggregation in cerebral infarction