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目的：探讨乳腺癌MRI特征与ER、PR、Her-2、Ki-67表达及淋巴结转移的相关性，为乳腺癌的疗效评价提供依据。方法28例乳腺癌患者行MR平扫、MR动态增强（ MR-DCE）及弥散加权成像（ DWI），分析MRI成像特征（大小、边缘、强化、TIC类型、ADC值），并与肿瘤标记物（ ER、PR、Her-2、Ki-67）表达、淋巴结转移进行相关性分析。结果①肿瘤标记物的表达及淋巴结转移：ER 阳性19例（67．86％）、PR 阳性18例（64．29％）、Her-2阳性15例（53．6％）、Ki-67阳性17例（60．71％）、淋巴结转移14例（50％）。②肿块型和非肿块型组、环形强化和非环形强化组与肿瘤标记物表达、淋巴结转移比较，差异无统计学意义。③肿瘤最大径＞2 cm和≤2 cm组比较，Her-2阳性表达率差异有统计学意义（χ2＝5．073，P＜0．05）；毛刺征和非毛刺征两组比较，PR阳性表达率差异有统计学意义（χ2＝6．857， P＜0．05）。④淋巴结转移率在TICⅡ型与Ⅲ型组比较，差异有统计学意义（χ2＝7．337，P＜0．05）；ADC值在Her-2阳性和阴性组间比较，差异有统计学意义（t＝5．624，P＜0．01）。结论乳腺癌MRI征象（大小、毛刺征、TIC类型、ADC值）与肿瘤标记物（PR、Her-2）表达、淋巴结转移具有较高的相关性，分析MR征象有助于乳腺癌疗效的评价。“,”Objective To investigate the correlation between the MRI features of breast cancer and expression of ER, PR, HER-2, Ki-67 and lymph node metastasis, so as to provide basis for therapeutic evaluation of breast cancer.Methods We carried out MR plain scan, MR dynamic enhancement ( MR-DCE) and diffusion weighted imaging on 28 breast cancer patients;analyzed MRI ima-ging features ( size, edge, enhancement, TIC type and ADC value);and conducted correlation analysis with expression of tumor mark-ers ( ER, PR, Her-2, ki-67) and lymph node metastasis.Results ①Expression of tumor markers and lymph node metastasis:nine-teen cases of ER positive (67.86%), eighteen cases of PR positive (64.29%), fifteen cases of Her-2 positive (53.6%), seventeen cases of Ki-67 positive (60.71%) and fourteen cases of lymph node metastasis(50.00%);②There was no statistical significance in the difference of tumor marker expression and lymph node metastasis between mass type and non-mass type groups as well as ring en-hancement and non-ring enhancement groups.③There was statistical significance (χ2 =5.073,P2 cm and≤2 cm;Statistical significance (χ2 =6.857,P<0. 05 ) was seen in the difference of PR positive expression rates between the spicule sign and non-spicule sign groups.④Statistical signif-icance (χ2 =7.337,P<0.05) was found in the difference between lymph node metastasis rate TIC II type and III type groups;and that (t=5.624,P<0.01) was found in the difference of ADC value between Her-2 positive and negative groups.Conclusion The MRI imaging features ( size, spicule sign, TIC type, ACD value) have relatively high correlation with expression of tumor markers ( PR, Her-2) and lymph node metastasis.Analyzing these features is helpful for therapeutic evaluation of breast cancer.