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对54例广西地区宫颈癌组织活检标本进行HPV 16型基因组相关序列检测及病理切片检查,发现:(1)13例HPV 16型和3例HPV 11/6型均为鳞癌,6例HPV R型中有4例也为鳞癌。16型的13例中有8例为低分化癌,R型的6例中有5例也为低分化癌。(2)不同型别HPV感染的宫颈癌组织,其病理形态学待征有所不同。(3)Southern blot核酸杂交技术和病理形态学检查,二种方法判断HPV感染及其型别,结果是基本一致的。
A total of 54 cases of cervical cancer tissue biopsies from Guangxi province were detected by HPV 16 genomic sequence and pathological examination. The results showed that: (1) 13 cases of HPV type 16 and 3 cases of HPV type 11/6 were squamous cell carcinoma, 6 cases of HPV R There are also 4 cases of squamous cell carcinoma. Eight of the 13 cases of type 16 were poorly differentiated and 5 of 6 cases of type R were poorly differentiated. (2) Different types of HPV infection of cervical cancer, the pathological morphology of levy is different. (3) Southern blot hybridization and pathological examination, two methods to determine HPV infection and its type, the results are basically the same.