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目的 探讨内毒素对脐静脉内皮细胞分泌功能的影响。方法 选择体外培养的人脐静脉血管内皮细胞（ＨＵＶＥＣ）为研究对象，分别用内毒素、Ｌ左旋精氨酸和硝基左旋精氨酸进行处理，并检测上清液中内皮素１（ＥＴ１）和一氧化氮（ＮＯ） 含量。结果 内毒素使ＥＴ１ 和ＮＯ 含量增加；ＮＯ 则使ＥＴ１的含量降低。结论 内毒素能导致人脐静脉内皮细胞损伤，使ＥＴ１ 和ＮＯ的合成和释放增加；ＮＯ则抑制ＥＴ１ 的合成和释放。
Objective To investigate the effects of endotoxin on the secretion of umbilical vein endothelial cells. Methods Human umbilical vein endothelial cells (HUVECs) were cultured in vitro and treated with endotoxin, L-L-arginine and L-arginine respectively. Endothelin-1 1) and nitric oxide (NO) content. Endotoxin ET 1 and NO content increased; NO ET 1 content decreased. Conclusion Endotoxin can lead to human umbilical vein endothelial cell injury, so ET 1 and NO synthesis and release increased; NO inhibits ET 1 synthesis and release.