抗痫药可导致神经系统的毒副作用,如可引起脑病、小脑功能障碍、诱发或加重癫痫发作,亦可孤立出现锥体外系功能失调和周围神经病变,甚至影响脑电图变化,现简述如下。脑病早在1964年,已观察到用大剂量抗痫药的病人可发生神经病学综合征,临床表现有很大差异。最多见的是引起小脑和脑干功能紊乱,表现为平衡、步态、语言失调和眼球震颤,血浆苯妥因钠和卡马西平等药浓度升高。因此,有的学者认为抗痫药脑病是指一种可逆综合征,如进行性智力减退、脑干和小脑症群、癫痫发作频率增加。卡马 Antiepileptic drugs can cause side effects of the nervous system, such as causing encephalopathy, cerebellar dysfunction, induced or aggravated seizures, isolated extrapyramidal disorders and peripheral neuropathy, or even affect the EEG changes, is now outlined as follows. Encephalopathy As early as 1964, neurological syndromes have been observed in patients with high-dose antiepileptic drugs, and clinical manifestations vary widely. The most common cause is cerebellar and brainstem dysfunction, manifested as balance, gait, speech disorders and nystagmus, plasma phenytoin sodium and carbamazepine equal concentrations. Therefore, some scholars believe that anti-epileptic drug encephalopathy is a reversible syndrome, such as progressive mental retardation, brainstem and cerebellar syndrome, seizures increased frequency. Kama