论文部分内容阅读
目的了解宫颈癌的发病与血管内皮生长因子(VEGF)的相关性研究。方法应用LSAB免疫组织化学技术,检测63例宫颈癌及19例正常宫颈组织标本中VEGF的表达。结果宫颈癌组织中VEGF的阳性表达率为53.9%(34/63),而正常宫颈组织中VEGF均为阴性表达;肿瘤直径≥4cm或间质浸润≥1/2的宫颈癌病人VEGF阳性表达率明显高于肿瘤直径<4cm或间质浸润<1/2者)(χ2=4.52、4.00,P<0.05)。有宫颈旁浸润或盆腔淋巴结转移者VEGF的阳性表达率显著高于无宫颈旁浸润的淋巴结转移者(χ2=4.48、7.27,P<0.05)。结论VEGF表达与宫颈癌的局部浸润和转移有关,可作为判断宫颈癌生物学行为的指标之一。
Objective To investigate the correlation between the incidence of cervical cancer and vascular endothelial growth factor (VEGF). Methods LSAB immunohistochemistry was used to detect the expression of VEGF in 63 cases of cervical cancer and 19 cases of normal cervical tissue. Results The positive expression rate of VEGF in cervical cancer was 53.9% (34/63), while the expression of VEGF was negative in normal cervical tissue. The positive rate of VEGF expression in cervical cancer with tumor diameter ≥4cm or interstitial infiltration≥1 / 2 Significantly higher than tumor diameter <4cm or interstitial infiltration <1/2) (χ2 = 4.52,4.00, P <0.05). The positive rate of VEGF expression in patients with cervical or pelvic lymph node metastasis was significantly higher than those without lymph node metastasis (χ2 = 4.48, 7.27, P <0.05). Conclusion The expression of VEGF is related to the local infiltration and metastasis of cervical cancer, which may be used as one of the indicators to judge the biological behavior of cervical cancer.