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趋化因子是指由白细胞和某些基质细胞分泌的、可结合在内皮细胞表面、对中性粒细胞、单核细胞、淋巴细胞具有趋化和激活作用的细胞因子。趋化因子在炎症反应中具有重要作用，可吸引白细胞移行到感染部位的一些低分子量蛋白质。随着对其的深入研究发现，趋化因子与其受体共同构成的网络系统与多种肿瘤的发生、发展相关。研究还发现，CXC类趋化因子亚家族的成员之一的趋化因子C-X-C趋化因子配体12及其受体C-X-C趋化因子受体4、C-X-C趋化因子受体7，与非霍奇金淋巴瘤的多种生物学过程相关。“,”Chemokine,a kind of cytokines,which is secreted by white blood cells and stromal cells,can combine with the surface of endothelial cells , and has the function of chemotaxis and activation of neutro-phils,monocytes,and lymphocytes.Chemokines play an important role in the inflammatory response ,as it can attract leucocyte migrate to some low molecular weight protein located in the infected site .With the in-depth study of chemokines,it′s found that network systems,constituted with chemokines and their receptors,are associated with the occurrence and development of a variety of tumors.It′s also found that CXCL12,one of the members of CXC chemokines,and its receptor CXCR4,CXCR7 are associated with some of the biological processes of non-Hodgkin lymphoma .