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癫痫是儿童的常见病之一,丙戊酸钠(valproicacid,VPA)是治疗癫痫病的常用药物,它所造成的肝脏损害是癫痫治疗中常见的不良反应之一,其发生率占40%[1],且是引起肝衰竭的主要药物[2],具有明显的年龄特异性,临床上0~2岁VPA单药和合并多药治疗癫痫者,合并致死性肝毒性的发生率分别
Epilepsy is one of the most common childhood diseases. Valproic acid (VPA), a commonly used drug for the treatment of epilepsy, is one of the most common adverse reactions in the treatment of epilepsy. The incidence of liver damage is 40% 1], and is the main cause of liver failure [2], with significant age-specific clinical 0-2-year-old VPA monotherapy and multi-drug treatment of epilepsy, the incidence of fatal hepatotoxicity were