虽然有大量实验早已证实单纯压力超负荷即可诱导心肌肥大 ,但是至今尚不清楚这一力学作用的信号转导机制。有报道指出 ,细胞形变可直接刺激细胞内腺苷酸环化酶活性及ｃＡＭＰ含量升高。本室研究也提示 ,急性压力超负荷可诱导心肌组织ｃＡＭＰ含量迅速升高、ｃＧＭＰ含量迅速降 Although a large number of experiments have long proved that simple pressure overload can induce cardiac hypertrophy, so far the mechanism of signal transduction of this mechanistic effect is not clear. It has been reported that cell deformation can directly stimulate intracellular adenylate cyclase activity and cAMP content increased. Our study also suggests that acute pressure overload can induce myocardial cAMP content increased rapidly, cGMP content decreased rapidly