近几十年,欧美国家食管胃连接处腺癌(AEG)的发病率快速上升,过去食管癌以鳞状细胞癌为主,近来下段食管和食管胃连接处腺癌占新发病例半数以上,胃癌的发生部位也从远侧胃向近侧胃转变。在美国,AEG发病率上升速度超过了其他任何恶性肿瘤,成为当今临床的重要研究课题之一[1-4]。1A In recent decades, the incidence of esophageal-gastric adenocarcinoma (AEG) in European and American countries has risen rapidly. In the past, esophageal cancer was predominantly squamous cell carcinoma. Recently, the lower esophagus and esophagogastric junction adenocarcinoma accounted for more than half of new cases, The site of gastric cancer also changes from the distal stomach to the proximal stomach. In the United States, the incidence of AEG surpasses that of any other malignant tumor and has become one of the most important research topics in clinical practice today [1-4]. 1A