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目的 :探讨E cadherin、nm2 3及CD4 4V6 蛋白与鼻咽癌 (NPC)的组织病理 ,转移及预后的关系。方法 :采用Elivision免疫组织化学方法检测其 5 9例鼻咽癌组织中E cadherin、nm2 3及CD4 4V6 基因产物的表达情况 ,分析它们与鼻咽癌患者的病理分型、颈部淋巴结转移情况、分期 ,以及生存期的关系。结果 :E cad蛋白在角化型鳞状细胞癌、分化型非角化性癌和未分化型癌组中的缺失表达率分别为 1/ 7、4 1 8% (14 / 34)、72 2 % (13/ 18) ,P <0 0 5。nm2 3蛋白保留表达组颈部淋巴结转移率为 2 3 8% (5 / 2 1) ,缺失表达组为 86 8% (33/ 38) ,P <0 0 5。其中在Ⅲ期鼻咽癌 (2 5例 )中 ,CD4 4V6 蛋白阳性表达组和阴性表达组 5年生存率分别为 15 4 % (2 / 13)和 6 6 7% (8/ 12 ) ,P <0 0 5 ;nm2 3蛋白保留表达和缺失表达组的 5年生存率分别为 6 / 9和 2 5 0 % (4 / 16 ) ,P <0 0 5。结论 :E cad蛋白表达与鼻咽癌的分化有关 ,nm2 3蛋白表达与鼻咽癌的颈淋巴结转移有关 ;CD4 4V6 蛋白阳性表达及nm2 3蛋白缺失表达是鼻咽癌预后不良的因素。
Objective: To investigate the relationship between E cadherin, nm23 and CD4 4V6 protein and histopathology, metastasis and prognosis of nasopharyngeal carcinoma (NPC). Methods: The expressions of E cadherin, nm23 and CD4 4V6 in 59 NPC tissues were detected by Elivision immunohistochemistry. Their pathological types, cervical lymph node metastasis, Staging, and survival of the relationship. RESULTS: The deletion rates of E cad protein in keratinized squamous cell carcinoma, differentiated non-keratinizing carcinoma and undifferentiated carcinoma were 1 / 7,4 1 8% (14/34), 72 2 % (13/18), P <0 0 5. The rate of cervical lymph node metastasis was 23.8% (5/21) in the nm23 protein expression group and 86.8% (33/38) in the null expression group, P <0.05. Among them, the 5-year survival rates of CD4 + 4V6 protein positive group and negative expression group were 15 4% (2/13) and 6 6 7% (8/12) in stage Ⅲ nasopharyngeal carcinoma (25 cases), P The 5-year survival rates of the nm23 protein expression-deleted group were 6/9 and 25% (4/16), respectively, P <0 05. Conclusion: The expression of E-cadherin is related to the differentiation of nasopharyngeal carcinoma. The expression of nm23 protein is related to the metastasis of cervical lymph node. The positive expression of CD4 4V6 protein and the loss of nm23 protein are the prognostic factors of NPC.