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目的初步了解拉萨地区围产儿出生缺陷发生情况,探索相关影响因素。方法对拉萨市人民医院2012年1月至2015年12月出生的7 014例围产儿出生缺陷资料进行回顾性分析。结果围产儿共7 014例,出生缺陷59例,发生率为8.41‰。出生缺陷的顺位排序前5位依次为:多指(趾)畸形、唇腭裂、神经管畸形、脑积水、马蹄足内(外)翻。Logistic多因素回归分析,产妇文化程度和产检次数对出生缺陷率的影响有统计学意义(P<0.05)。结论拉萨地区应健全出生缺陷筛查体制;重视三级预防,推行规范产前筛查和产前诊断,减少缺陷儿出生,提高人口质量。
Objective To understand the incidence of perinatal birth defects in Lhasa and explore the related factors. Methods The data of 7 014 cases of perinatal birth defects in Lhasa People’s Hospital from January 2012 to December 2015 were retrospectively analyzed. Results A total of 7 014 perinatal infants, birth defects in 59 cases, the incidence was 8.41 ‰. The order of birth defects ranked the top 5 were: multiple finger (toe) deformity, cleft lip and palate, neural tube defects, hydrocephalus, clubfoot (outside) turn. Logistic multivariate regression analysis, maternal education and number of births had a significant effect on birth defects rate (P <0.05). Conclusion The screening system for birth defects should be improved in Lhasa. Three levels of prevention should be emphasized. Prenatal screening and prenatal diagnosis should be implemented to reduce the birth of defective children and improve the quality of the population.