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目的:探讨新辅助化疗在局部晚期宫颈癌治疗中的临床效果及患者的生存情况。方法:回顾性分析2006年2月至2012年2月行新辅助化疗联合根治性手术的局部晚期宫颈癌患者168例的临床资料。结果:本组168例中ⅠB2期55例,ⅡA期67例,ⅡB期46例;化疗有效率为62.5%,3年无病生存率和总生存率分别为69%和72%,生存分析表明肿瘤的浸润深度、有无脉管浸润、淋巴结转移及肿瘤对化疗的反应与患者的生存预后相关(P<0.05)。结论:新辅助化疗可作为局部晚期宫颈癌患者治疗策略的一种选择。
Objective: To investigate the clinical effect of neoadjuvant chemotherapy in the treatment of locally advanced cervical cancer and its survival. Methods: The clinical data of 168 patients with locally advanced cervical cancer undergoing neoadjuvant chemotherapy combined with radical surgery from February 2006 to February 2012 were retrospectively analyzed. Results: The group of 168 cases ⅠB Ⅰ 55 cases, ⅡA 67 cases, ⅡB 46 cases; chemotherapy was 62.5%, 3-year disease-free survival and overall survival were 69% and 72%, respectively, survival analysis showed that The depth of tumor invasion, vessel invasion, lymph node metastasis and tumor response to chemotherapy were related to the prognosis of patients (P <0.05). Conclusion: Neoadjuvant chemotherapy can be used as a treatment option for patients with locally advanced cervical cancer.