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采用回顾性研究方法,从患者年龄、临床表现、药物种类、抗菌药物类别等方面对2013年江苏省扬州市某三级甲等医院243例的ADR/ADE进行统计分析。ADR/ADE患者中性别比例基本相当,高发年龄段为小于18岁和大于60岁患者;ADR在临床表现主要集中在皮肤和消化系统。皮肤及其附件最多,临床主要表现为皮肤瘙痒、皮疹、荨麻疹和斑疹等。发生部位为消化系统的临床主要表现为恶心、呕吐、上腹胀痛、消化道出血和肝功能异常等;抗感染药物和中药制剂是引发ADR/ADE发生的主要药品种类,头孢菌素类和青霉素类是引起ADR/ADE的抗感染药物主要品种。
A retrospective study was conducted to analyze the ADR / ADE of 243 patients from a tertiary level Hospitals in Yangzhou City, Jiangsu Province, in terms of patient’s age, clinical manifestations, types of drugs and antibacterials. ADR / ADE patients in the proportion of the same gender, high incidence of age less than 18 years of age and patients over 60 years; ADR clinical manifestations mainly in the skin and digestive system. Most of the skin and its annexes, the main clinical manifestations of itching skin, rash, urticaria and rash. The main clinical manifestations of the site of the digestive system were nausea, vomiting, abdominal pain, gastrointestinal bleeding and abnormal liver function. Anti-infectives and traditional Chinese medicines were the main drugs that caused ADR / ADE. Cephalosporins and Penicillins are the major anti-infective drugs that cause ADR / ADE.