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用试管双倍稀释法测定磺苄西林(Sulbenicil-lin)、羧苄青霉素、氨苄青霉素、哌拉西林(Piperacil-lin)和头孢噻肟对20株粘液型和50株非粘液型绿脓杆菌的体外抗菌活性。结果表明,细菌接种量为10~(-4)CF U/ml 时,磺苄西林的抗菌活性较羧苄青霉素强,但较哌拉西林和头孢噻肟弱。显然,这些细菌对受试的β-内酰胺抗生素具高度耐药性,尤当细菌接种量为10~7CF U/ml 时更为明显。哌拉西林和头孢噻肟在接种量为10~7 CFμ/ml 时的抗菌活性较10~4时为小,这在杀菌浓度时更为明显。磺苄西林、羧苄青霉素和头孢噻肟的MBC/MIC 比率范围为1～2,而哌拉西林则为3～
Piperazine and cefotaxime against 20 strains of mucoid and 50 strains of non-mucilaginous Pseudomonas aeruginosa were assayed by in vitro double-dilution assay using Sulbenicil-lin, carbenicillin, ampicillin, piperacil- In vitro antibacterial activity. The results showed that antibacterial activity of carbenicillin was stronger than carbenicillin when the inoculum size was 10 ~ (-4) CFU / ml, but weaker than piperacillin and cefotaxime. Obviously, these bacteria are highly resistant to the beta-lactam antibiotics tested, especially when bacterial inoculation is 10-7 CFU / ml. Piperacillin and cefotaxime inoculation of 10 ~ 7 CFμ / ml antibacterial activity than 10 to 4 hours is small, which is more obvious when the bactericidal concentration. The MBC / MIC ratios for carbenicillin, carbenicillin and cefotaxime ranged from 1 to 2, whereas for piperacillin,