论文部分内容阅读
目的分析慢性阻塞性肺疾病急性加重期并肺动脉高压患者呼出气一氧化氮(Fe NO)浓度变化及其临床意义。方法选取2015年5月—2016年5月咸阳市第一人民医院收治的慢性阻塞性肺疾病急性加重期并肺动脉高压患者30例作为A组,慢性阻塞性肺疾病急性加重期患者30例作为B组;另选取同期在本院体检健康者30例作为C组。比较3组受试者及不同严重程度肺动脉高压患者Fe NO浓度及血清一氧化氮合酶(NOS)水平。结果 A组患者Fe NO浓度及血清NOS水平低于B、C组,B组患者Fe NO浓度及血清NOS水平低于C组(P<0.05)。重度肺动脉高压患者Fe NO浓度及血清NOS水平低于轻、中度肺动脉高压患者,中度肺动脉高压患者Fe NO浓度及血清NOS水平低于轻度肺动脉高压患者(P<0.05)。结论慢性阻塞性肺疾病急性加重期并肺动脉高压患者Fe NO浓度明显降低,且其与肺动脉高压严重程度相关。
Objective To analyze the changes and clinical significance of exhaled nitric oxide (NO) concentration in patients with chronic exacerbation of chronic obstructive pulmonary disease and pulmonary hypertension. Methods From May 2015 to May 2016, 30 cases of acute exacerbation of chronic obstructive pulmonary disease and pulmonary hypertension in the First People’s Hospital of Xianyang City were enrolled as group A. 30 cases of acute exacerbation of chronic obstructive pulmonary disease In addition, 30 healthy people in our hospital were selected as group C in the same period. FeNP concentrations and serum nitric oxide synthase (NOS) levels were compared between the three groups of patients and patients with different severity of pulmonary hypertension. Results Fe NO concentration and serum NOS level in patients in group A were lower than those in patients in groups B and C. Fe concentration and serum NOS level in patients in group B were lower than those in group C (P <0.05). Patients with severe pulmonary hypertension Fe NO concentration and serum NOS levels were lower than mild to moderate pulmonary hypertension in patients with moderate pulmonary hypertension Fe NO concentration and serum NOS levels were lower than mild pulmonary hypertension patients (P <0.05). Conclusion The concentration of Fe-NO in acute exacerbation of chronic obstructive pulmonary disease and pulmonary hypertension patients is significantly lower, and it is correlated with the severity of pulmonary hypertension.