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目的探讨乌司他丁联合磷酸肌酸钠对新生儿窒息后心肌损伤的影响。方法根据随机对照原则将267例窒息后心肌损伤患儿分为联合组134例和对照组133例。联合组给予乌司他丁联合磷酸肌酸钠治疗,对照组仅予磷酸肌酸钠治疗。治疗后观察2组临床疗效。结果联合组总有效率为95.52%高于对照组的76.69%,差异有统计学意义(P<0.05),治疗组心肌酶改善水平显著优于对照组(P<0.01)。结论乌司他丁联合磷酸肌酸钠治疗新生儿窒息后心肌损伤疗效显著,能明显改善患儿临床症状和心肌功能,降低再灌注损伤,建议临床广泛推广应用。
Objective To investigate the effect of ulinastatin combined with sodium creatine phosphate on neonatal asphyxia myocardial injury. Methods According to the principle of randomized control, 267 children with post-asphyxial myocardial injury were divided into 134 cases in combined group and 133 cases in control group. The combination group was treated with ulinastatin and sodium creatine phosphate, while the control group only with sodium phosphate creatine. Two groups were observed after treatment efficacy. Results The total effective rate in the combined group was 95.52%, which was significantly higher than that in the control group (76.69%, P <0.05). The improvement of myocardial enzymes in the treatment group was significantly better than that in the control group (P <0.01). Conclusion Ulinastatin combined with sodium creatine phosphate treatment of neonatal asphyxia myocardial infarction significant effect, can significantly improve children with clinical symptoms and myocardial function, reduce reperfusion injury, it is recommended that the clinical application of a wide range.