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目的 :探讨米非司酮联合米索前列醇治疗稽留流产的临床价值。方法 :选取2014年06月至2016年05月我院妇科稽留流产患者42例作为观察组,同期瘢痕子宫合并早孕要求药流及虽不是瘢痕子宫但妊娠达10-14周的早孕对象42例作为对照组,均给予米非司酮配伍米索前列醇联合清宫术治疗,观察比较两组的疗效及手术情况。结果 :稽留流产的观察组患者不完全流产率明显高于终止正常妊娠的对照组患者,p<0.01有统计学意义;两组患者排胎后2h内的阴道出血量组间比较,观察组患者流血量明显多于对照组,组间差异明显有统计学意义(p<0.01);两组从开始服用米索前列醇到妊娠物排出的时间差异无统计学意义(p>0.05);两组患者均出现轻中度恶心呕吐、腹泻、寒战、发热、疲乏等症状,但组间差异不明显,无统计学意义(p>0.05)。结论 :米非司酮配伍米索前列醇联合清宫术用于治疗稽留流产,是一种安全性好、有效性高的理性疗法,有较好的临床应用价值。
Objective: To investigate the clinical value of mifepristone combined with misoprostol in the treatment of missed abortion. Methods: Forty-two patients with gynecological missed abortion in our hospital from June 2014 to May 2016 were selected as the observation group. 42 cases of pregnant women who did not have the scar uterus but whose pregnancy was 10-14 weeks were selected as control group Group, were given mifepristone combined with misoprostol in combination with curettage, observed and compared the efficacy of the two groups and surgery. Results: The incomplete abortion rate in observed abortion group was significantly higher than that in control group with normal pregnancy, p <0.01 was statistically significant; vaginal bleeding within 2h after abortion in both groups were compared between groups. Patients in observation group (P <0.01). There was no significant difference in the time of excretion of misoprostol between the two groups (p> 0.05); both groups Patients showed mild to moderate nausea and vomiting, diarrhea, chills, fever, fatigue and other symptoms, but no significant difference between the groups, no statistical significance (p> 0.05). Conclusion: Mifepristone combined with misoprostol combined with curettage in the treatment of missed abortion is a rational and effective therapy with good safety and good clinical value.