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目的 探讨甲基强的松龙冲击疗法对难治性肾病综合征的疗效。方法 选择 38例难治性肾病综合征患儿 ,给予甲基强的松龙每次 2 0～ 30 mg/kg,加入 1 0 %葡萄糖溶液 1 0 0 ml中静滴 ,1 /d,连用 3d,第 4～ 7d口服强的松 2 m g/( kg· d)。未完全缓解者重复第二疗程。结果 冲击治疗后 ,血浆白蛋白有不同程度的升高 ,2 4 h尿蛋白定量、血胆固醇、血肌酐 ( Cr)、尿素氮 ( BU N)有明显降低 ,冲击治疗前后相差有高度显著性 ( P<0 .0 1 )。随着 MP冲击疗程增加 ,完全及部分缓解例数增多。结论 甲基强的松龙冲击疗法可以使难治性肾病达到较稳定的缓解及保护肾功能 ,尤其对早期病例效果较好 ,但必须通过前瞻性对照研究加以证实。
Objective To investigate the effect of methylprednisolone impact therapy on refractory nephrotic syndrome. Methods Thirty-eight children with refractory nephrotic syndrome were enrolled and given methylprednisolone 20-30 mg / kg every time. The animals were treated with intravenous drip of 100% glucose solution for 1 / , 4 ~ 7d oral prednisone 2 mg / (kg · d). Patients who did not complete remission repeated the second course of treatment. Results After the shock treatment, plasma albumin increased to different extents. The urinary protein excretion at 24 h was significantly lower than that before treatment (P <0.05). The levels of blood cholesterol, serum creatinine (Cr) and blood urea nitrogen (BU N) P <0 .0 1). As MP shock therapy increases, the number of cases of complete and partial response increases. Conclusion Methylprednisolone impact therapy can make refractory nephropathy achieve more stable relief and protection of renal function, especially in early cases, but it must be confirmed by prospective controlled study.