论文部分内容阅读
Counsell氏1970年首先合成放射性~(131)碘化胆固醇(1)。次年,Beierwaltes等氏将它用于肾上腺闪烁扫描,以显示人类肾上腺(2)。由于胆固醇为肾上腺激素的主要前身,迄今为止,临床上已将其应用于一些肾上腺疾病,如原发性醛固醇增多症、皮质醇增多症和嗜铬细胞瘤等的诊断。文献中曾报导过各种放射性碘化胆固醇类物质,例如放射性碘化CL—19—I,NCI—6—I,~(131)I—NP—59等在动物脏器内的分布(3)、(4)、(5)、(6),研究它们在动物体内不同脏器的分布代谢特点,作为临床使用时的重要参考。
In 1970, Counsell first synthesized radioactive 131 iodinated cholesterol (1). The following year, Beierwaltes et al. Used it for adrenal scintigraphy to show the human adrenal gland (2). Since cholesterol is the main predecessor of adrenal hormones, so far, it has been clinically applied to the diagnosis of some adrenal diseases such as primary hyperaldosteronism, cortisolism and pheochromocytoma. The distribution of various radioiodinated cholesterol substances such as radioiodinated CL-19-I, NCI-6-I, 131 I-NP-59 and the like in animal organs has been reported in the literature (3) , (4), (5), (6), to study their distribution in different organs of animals metabolic characteristics, as an important reference for clinical use.