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目的：为了解ＬＣ患者血浆ＥＴ、ＣＧＲＰ水平，探讨其临床意义。方法：采用放射免疫分析法检测健康成人及ＬＣ患者血浆ＥＴ、ＣＧＲＰ水平。结果：ＬＣ组血浆ＥＴ１明显高于对照组（Ｐ＜０．０１），ＣＧＲＰ明显低于对照组（Ｐ＜０．０１）。ＬＣ组内ＥＴ１、ＣＧＲＰ水平与肝功分级、血浆蛋白及ＡＬＴ、ＡＳＴ值无明显相关性（Ｐ＞０．０５）。结论：作为血管活性物质ＥＴ与ＣＧＲＰ相互拮抗，调节门脉压力保持动态平衡。ＬＣ门脉高压的形成和发展与ＥＴ升高、ＣＧＲＰ下降有关。探讨二者之间的关系将有助于加深对ＬＣ及其并发症的认识，有助于对新的降门脉压药物的探索
Objective: To understand the plasma levels of ET and CGRP in patients with LC and to investigate its clinical significance. Methods: Plasma ET and CGRP levels were measured by radioimmunoassay in healthy adult and LC patients. Results: The plasma ET1 in LC group was significantly higher than that in control group (P <0.01), and CGRP was significantly lower than that in control group (P <0.01). The level of ET1 and CGRP in LC group had no significant correlation with the grade of liver function, plasma protein, ALT and AST (P> 0.05). CONCLUSION: As a vasoactive substance, ET and CGRP antagonize each other and regulate portal pressure to maintain homeostasis. The formation and development of LC portal hypertension and ET increased, CGRP decreased. To explore the relationship between the two will help to deepen the understanding of LC and its complications, help to explore new drugs to reduce portal pressure