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目的 :探讨血清血管内皮生长因子 (vascular endothelial growth factor,VEGF)在乳腺癌诊断、预后及疗效观察中的意义。方法 :用双抗夹心 EL ISA方法测定 40例乳腺癌患者血清的VEGF水平 ,另用 40名健康人的血清 VEGF水平作对照。用 SPSS10 .0统计软件包进行统计分析。结果 :乳腺癌患者血清 VEGF水平显著高于健康人 (P =0 .0 0 0 ) ;晚期乳腺癌 ( 期、 期 )患者血清VEGF水平高于早期乳腺癌 ( 期、 期 )患者 ,差异有显著性 (P=0 .0 0 2 ) ;有淋巴结转移者高于无淋巴结转移者 (P=0 .0 0 3 )。结论 :血清 VEGF可能成为乳腺癌的一个新的肿瘤标志物 ,用于乳腺癌的诊断和动态监测病情进展、预后判断
Objective: To investigate the significance of serum vascular endothelial growth factor (VEGF) in the diagnosis, prognosis and curative effect of breast cancer. Methods: The serum levels of VEGF in 40 patients with breast cancer were measured by double-antibody sandwich ELISA. Another 40 healthy people were used as control. SPSS10 .0 statistical package for statistical analysis. Results: Serum VEGF levels in patients with breast cancer were significantly higher than those in healthy individuals (P = 0.000). The serum VEGF levels in patients with advanced breast cancer (stage and stage) were significantly higher than those in patients with early stage breast cancer (stage and stage) (P = 0.002). Those with lymph node metastasis were higher than those without lymph node metastasis (P = 0.0030). Conclusion: Serum VEGF may become a new tumor marker of breast cancer, which is used in the diagnosis of breast cancer and dynamic monitoring of disease progression and prognosis