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目的:基于不同小鼠模型评价针灸防治阿尔茨海默病(AD)的效应.方法:根据AD的病理生理学成因,选择具有代表性的小鼠模型,包括SAMP8快速老化小鼠、Aβ注射小鼠/大鼠、淀粉样前蛋白(APP)转基因小鼠以及APP/PS1双转基因小鼠,通过对行为变化的观察和对核心指标的分析,探讨针灸防治AD的可能效应机制.结果:针灸干预确实能够改善AD小鼠的认知功能;其主要作用机制包括增加脑血流量,增强海马体关键蛋白质的表达,阻止神经细胞凋亡,加快Aβ沉积的清除,激活自噬途径减少记忆缺失,以及调节脑源性神经生长因子、酪氨酸激酶受体B、N-乙酰天冬氨酸和谷氨酸的代谢.结论:虽然没能确定最佳的AD小鼠模型,但是针灸能有效改善认知功能的作用是肯定的.为更好揭示针灸防治AD的内在效应机制,需要寻找更合适的AD模型.“,”Objective: To evaluate the prevention and treatment effects of acupuncture-moxibustion for Alzheimer disease (AD) based on various AD mouse models.Methods: Several representative types of mouse models were selected according to the pathophysiological causes of AD, including senescence accelerated mouse/prone (SAMP) mice, soluble amyloid-β protein (Aβ) injection mice/rats, amyloid precursor protein (APP) transgenic mice, and APP/PS1 double transgenic mice. Through the observation of behavioral changes and analysis of core items, the possible mechanisms of acupuncture-moxibustion in preventing and treating AD were explored. Results: Acupuncture-moxibusiton therapy can improve AD mice's cognitive dysfunction; the major action mechanisms including increasing cerebral blood flow, improving the expressions of vital proteins in the hippocampus, preventing neuron cell apoptosis, promoting the clearance of Aβ deposition, activating autophagy pathway to reduce memory deficits and regulating the metabolisms of brain-derived neurotrophic factor, tyrosine kinase receptor B, N- acetylaspartate and glutamic acid. Conclusion: Although the optimal mouse model is not determined, it is sure that acupuncture-moxibustion therapy can improve cognitive function. A more suitable AD animal model should be duplicated in order to better explore the inherent action mechanism of acupuncture-moxibustion in preventing and treating AD.