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目的研究高同型半胱氨酸血症(HHcy)与颈动脉狭窄的关系。方法应用循环酶法测定90例急性脑梗死(ACI)患者血浆同型半胱氨酸(Hcy)浓度,并采用彩色多普勒超声进行颈动脉检测并与正常对照组比较。结果 ACI组血浆Hcy水平显著高于正常对照组(P<0.001),ACI组中颈动脉重度狭窄者血浆Hcy浓度显著高于中度狭窄者及无狭窄或轻度狭窄者(P<0.01),中度狭窄者血浆Hcy浓度显著高于无狭窄或轻度狭窄者(P<0.01)。结论 Hcy水平与脑梗死患者颈动脉狭窄的严重程度相关。
Objective To investigate the relationship between hyperhomocysteinemia (HHcy) and carotid artery stenosis. Methods Cyclic homocysteine (Hcy) levels in 90 patients with acute cerebral infarction (ACI) were determined by enzymatic cycling method. The carotid artery was detected by color Doppler sonography and compared with the normal control group. Results The plasma Hcy level in ACI group was significantly higher than that in normal control group (P <0.001). The plasma Hcy concentration in severe carotid stenosis group was significantly higher than that in moderate stenosis group and no stenosis group or mild stenosis group (P <0.01) Moderately stenosed plasma Hcy concentrations were significantly higher than those without stenosis or mild stenosis (P <0.01). Conclusions The level of Hcy is correlated with the severity of carotid artery stenosis in patients with cerebral infarction.