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目的:筛选单侧全膝关节置换术后急性疼痛的危险因素。方法:2019年5月至2019年12月择期全麻下行首次单侧全膝关节置换术患者，收集术前一般资料以及PainDETECT量表评分、西安大略麦克马斯特大学骨关节炎评分、焦虑抑郁量表评分、VAS评分、是否服用阿片类药物；术中使用止血带时间以及麻醉药物使用情况；术后24 h内记录膝关节VAS评分，将患者分为2组，VAS评分≤3分为轻度疼痛组(L组)，VAS评分>3分为中至重度疼痛组(H组)，将组间比较差异有统计学意义的因素进行logistic回归分析，筛选单侧全膝关节置换术后急性疼痛的危险因素。结果:共143例患者纳入本研究，其中L组60例，H组83例，术后中到重度急性疼痛发生率为58%。患者术前VAS评分、焦虑状态、并存神经病理性疼痛及术中使用止血带时间是单侧全膝关节置换术后急性疼痛的危险因素(n P3) group (group H). The factors of whichn P values were less than 0.05 would enter the logistic regression analysis to stratify the risk factors for acute pain after unilateral TKA.n Results:A total of 143 patients were included in this study, including 60 patients in group L and 83 patients in group H. The incidence of moderate to severe acute pain after surgery was 58%.Preoperative VAS score, anxiety status, coexisting neuropathic pain and intraoperative duration of tourniquet use were the risk factors for acute pain after unilateral TKA (n P<0.05).n Conclusion:Preoperative VAS score, anxiety state, coexisting neuropathic pain and intraoperative duration of tourniquet use are the risk factors for acute pain after unilateral TKA.