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目的 研究炎症性肠病患者抗中性粒细胞胞浆抗体(ANCA)的阳性率、特异性及与炎症程度病变范围的相关性,探讨ANCA作为溃汤性结肠炎患者辅助诊断指标的价值。方法 应用间接免疫荧光法检测42例溃疡性结肠炎患者、32例非溃疡性结肠炎引起的腹泻患者及35例正常对照者血清ANCA阳性率。结果 溃疡性结肠炎组pANCA阳性率为69.1％。非溃疡性结肠炎组总的pANCA阳性率为3.5％,P<0.05。pANCA对溃疡性结肠炎诊断的特异性为93.8％。核周型抗中性粒细胞胞浆抗体(pANCA)阳性率与病变范围无关(P>0.05)。结论 ANCA对炎症性肠病特别是溃疡性结肠炎的辅助诊断具有意义,同时具有较高的鉴别诊断价值。
Objective To investigate the positive rate and specificity of anti-neutrophil cytoplasmic antibody (ANCA) in patients with inflammatory bowel disease and its correlation with the extent of inflammation, and to explore the value of ANCA as an auxiliary diagnostic marker in patients with ulcerative colitis. Methods The serum ANCA positive rate of 42 patients with ulcerative colitis, 32 patients with non-ulcerative colitis-induced diarrhea and 35 normal controls were detected by indirect immunofluorescence. Results The positive rate of pANCA in ulcerative colitis group was 69.1%. The total pANCA positive rate in non-ulcerative colitis group was 3.5%, P <0.05. The specificity of pANCA for the diagnosis of ulcerative colitis was 93.8%. The positive rate of perinuclear anti-neutrophil cytoplasmic antibody (pANCA) was not associated with the extent of the disease (P> 0.05). Conclusions ANCA is of significance for the auxiliary diagnosis of inflammatory bowel disease, especially for ulcerative colitis, and has high differential diagnostic value.