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在委内瑞拉进行的一随机,双盲疫苗试验中,给大约29 000例麻风病人接触者接种了热杀死的麻风分枝杆菌加卡介苗的混合物或只接种卡介苗。每年进行检查,以发现新发麻风病例。在试验开始时,采集所有接触者的血清。对其中13 020血清标本的抗PGL-I的抗体水平进行了分析。结果发现:抗体水平与接触者的各种特征有关。尽管由于接种疫苗可能改变了发病率,但仍然发现PGL-I抗体水平与麻风的发病危险之间有很强的相关性。在随访的4年中,血清中PGL-I抗体水平高的(为阳性对照血清抗体水平的
In a randomized, double-blind vaccine trial in Venezuela, some 29,000 leprosy contacts were vaccinated with heat-killed mixtures of M. leprae plus BCG or BCG alone. Check each year to find new leprosy cases. At the beginning of the experiment sera from all contacts were collected. Antibody levels of 1320 serum samples against PGL-I were analyzed. The results showed that: antibody levels and contact with the various characteristics. Although the incidence of leprosy may change as a result of vaccination, there is still a strong correlation between PGL-I antibody levels and the risk of developing leprosy. During the 4 years of follow-up, serum PGL-I antibody levels (as positive control serum antibody levels