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目的探讨多发性硬化(multiple sclerosis,MS)与抑郁、焦虑情感障碍的关系。方法采用汉密尔顿抑郁量表(Hamilton depression,HAMD)、汉密尔顿焦虑量表(Hamilton Anxiety,HAMA)、扩展的残疾状况评分(Expanded disability status scale,EDSS)量表对86例多发性硬化患者、85例健康对照者进行评分,了解MS伴发抑郁焦虑,同时应用多元回归分析方法对抑郁焦虑障碍的相关因素进行分析。结果 MS患者抑郁障碍发生率为52.3%(45例),焦虑障碍发生率为32.6%(28例),抑郁伴发焦虑26.7%(13例),均较对照组明显升高(P<0.01)。病情活动期、EDSS评分高者抑郁发生率亦高,女性患者抑郁发生率高。结论 MS患者抑郁焦虑发生率较高,早期识别及干预可以明显提高患者的生活质量。
Objective To investigate the relationship between multiple sclerosis (MS) and depression and anxiety disorders. Methods Eighty-six patients with multiple sclerosis and 85 healthy subjects were enrolled in this study. Hamilton depression scale (HAMD), Hamilton Anxiety Scale (HAMA), and Expanded disability status scale (EDSS) Control subjects were scored to understand the depression and anxiety associated with MS, and multivariate regression analysis was used to analyze the related factors of depression and anxiety disorders. Results The incidence of depression was 52.3% (45 cases), the incidence of anxiety disorder was 32.6% (28 cases) and the depression was associated with anxiety (26.7%, 13 cases), which were significantly higher than those in the control group (P <0.01) . Disease activity, high EDSS score depression is also high incidence of depression in women with high incidence. Conclusion The incidence of depression and anxiety in MS patients is high. Early recognition and intervention can significantly improve the quality of life of patients.