大骨节病是一种地方性的以软骨变性及坏死为主要病变的骨软骨疾病。近年来病理学的研究提示,深入了解大骨节病骨软骨的代谢变化,尤其是骨软骨基质成分(胶元及蛋白多糖等)的代谢变化,可能对于病因及发病机制的探讨以及该病的早期诊断等具有一定的意义。一般认为,尿中排出的羟脯氨酸及酸性氨基多糖是反映体内胶元和蛋白多糖代谢状况的两项 Kashin-Beck disease is a localized osteochondral disease characterized by degeneration and necrosis of the cartilage. In recent years, pathological studies suggest that in-depth understanding of the metabolic changes in bone and cartilage of Kashin-Beck disease, especially the metabolism of osteochondral matrix components (such as collagen and proteoglycan, etc.), may explore the etiology and pathogenesis of the disease and early Diagnosis has a certain significance. Is generally believed that the urine of hydroxyproline and acidic amino polysaccharide excretion is reflected in the body gum and proteoglycan metabolism of the two