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大剂量灭吐灵间歇性静脉注射是治疗细胞毒性药物所致呕吐的最佳治疗方法。但该法可使血浆浓度波动。而持续静脉注射可克服这一缺点,并能增强该药的止吐作用。冬眠灵被广泛用作止吐剂,但其止吐效果尚未与大剂量灭吐灵作过比较。本文作者采用随机分组的双盲试验来进行这一研究。病人与方法 95例(男43、女52例)采用细胞毒性药物进行第1疗程化疗的病人,药物中包括顺氯氨铂(cisplatin)者43例,不含该药者52例,随机分组给
High-dose metocloprazine intermittent intravenous injection is the best treatment for vomiting caused by cytotoxic drugs. However, this method can fluctuate plasma concentrations. Continuous intravenous injection can overcome this shortcoming and enhance the antiemetic effect of the drug. The hibernating spirit is widely used as an antiemetic agent, but its antiemetic effect has not been compared with a large-dose methaproterenil. The authors used a randomized, double-blind trial to conduct this study. Patients and Methods Ninety-five patients (43 males and 52 females) were treated with cytotoxic drugs for the first course of chemotherapy. There were 43 patients with cisplatin in the drug, and 52 patients without the drug. Randomly assigned to